However, it is very likely that more medicines will be developed or more discoveries will be made about this gene. Therefore it is important for you to remember this result and share it with other prescribing doctors. Re-emphasize relevance of test results for future treatments PCPs should remind patients of the potential significance of the current PGx test result for future treatments and encourage sharing of the test result with other providers.
Make referrals as necessary Some PGx variants not only affect drug responses but also disease risk. Conclusion Given the limited time with patients in a primary care setting, the amount of information that can be conveyed to patients about PGx testing will be quite limited.
Supplementary Figure An example of a patient letter for PGx testing following recommended content. Figure S1 Patient letter for PGx simvastatin testing. Reference 1. Footnotes Disclosure The authors report no conflicts of interest in this work. References 1. Genomics and drug response. N Engl J Med. Implementing genomic medicine in the clinic: the future is here. Genet Med. Pharmacogenomic biomarker information in drug labels approved by the United States Food and Drug Administration: prevalence of related drug use.
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Klitzman R. This information can be used by your healthcare provider to:. Each of us has a system of proteins that influence how we metabolize, transport, and respond to medications in our bodies. Using genetics to understand these proteins makes it possible to predict how effective a medication will be. Your body sees medications as impurities. As soon as a medication hits your bloodstream, your CYP begins breaking it down. How much of a given CYP enzyme your body produces is determined by your genes.
In general, if you have a lot, it will clean medications out of your bloodstream quickly. If you have only a little, the medication will build up over time. Typically, medication dosages are set for people with an average level of CYP enzymes. PGx testing helps your healthcare provider determine if your dose needs to be increased or decreased and whether a medication that works for most people might be ineffective or even dangerous for you.
One of the areas PGx testing is revolutionizing is in mental health treatment. Anxiety disorders are one of the most common psychiatric disorders in the U. Approximately 40 million American adults have some form of anxiety disorder.
The good news is that there are many different psychiatric medications available to help patients with anxiety. The bad news is that it can be challenging to find the right medication and dosage that both maximize effectiveness and minimize side effects and adverse drug reactions. For many common medications, a PGx test can help your doctor to provide the optimal prescription for you.
The results of a PGx test are likely to be most useful if you are:. Please note, there are some medications for which a PGx test is unlikely to provide useful information. Additionally, the pharmacogenomic guidance in a Sonic PGx panel report may not be valid in patients under 18 years of age.
The Sonic PGx panel is a blood test that examines the genetic variations you have in 10 specific genes. The PGx report informs your doctor of genetic variations that may influence how you respond to specific medications.
A comprehensive report is sent to your doctor. This report provides a focussed response regarding any medications identified by your doctor on the request form. The report also covers a wide range of medications that you may be prescribed in the future. Please note that this report is only one factor that your doctor will use in deciding what medications and dose to prescribe for you.
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